AFI #050 Tom Hanks as Jim Lovell from Apollo 13 (1995)

Jim Lovell:Well, between Jack's back taxes and the Fred Haise Show, I'd say that was a pretty successful broadcast.
CAPCOM: That was an excellent show, Odyssey.
Jack Swigert: Thank you very much, Houston.
CAPCOM: We've a couple of housekeeping procedures for you. We'd like you to roll right to 0-6-0 and null your rates.
Jack Swigert: Roger that. Rolling right, 0-6-0.
CAPCOM: And then if you could give your oxygen tanks a stir.
Jack Swigert: Roger that. [flips switches]
[Sparking, explosion]
[Alarm buzzing]
Jack Swigert: Hey, we've got a problem here.
Jim Lovell: What did you do?
Jack Swigert: Nothing. I stirred the tanks.
CAPCOM: Uh, this is Houston. Say again, please?
Jim Lovell: Houston, we have a problem.

- Tom Hanks as Jim Lovell from Apollo 13 (1995)

The bolded line is ranked #50 in the American Film Institute's list of the top 100 movie quotations in American cinema.

In real life, the quote was "Houston, we've had a problem." Apollo Expeditions to the Moon, ch. 13.1, by James A. Lovell. The original phrase pronounced by Jack Swigert, "Houston, we've had a problem here" and then repeated by Lovell, "Houston, we've had a problem", was altered to a present-tense in the film script.